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Reprogramming T Cells to Cross the Brain’s Border
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A Billion-Dollar Bet on AI-First Drug Development
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Finding New Targets on the Surface of Misfolded Proteins
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Targeting Tumors from the Inside Out
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An Effort to Detect and Treat Alzheimer’s at Its Earliest Stages
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The Year in Biotech and What’s Ahead for 2026
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Developing an Alternative to Opioids for Post-Surgical Pain
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Leveraging the Power of Vocal Biomarkers
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Determining the Cause and Severity of Sepsis with a Point-of-Care Test
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Separating Signal from Noise in Regenerative Therapies
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Rewriting Drug Discovery with an AI-Multi-Omics Approach
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Overcoming Chemoresistance and Activating the Immune System in Difficult-to-Treat Cancers
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A Hub-and-Spoke Ophthalmology Company with an Eye for Innovation
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An AI Collaborative that Welcomes All into the Fold
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Hitting the Reset Button on Cellular Aging
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Changing the Ovarian Cancer Treatment Landscape with a DNA-Mediated Immunotherapy
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Why the United States Must Fall in Love with Biotechnology, or Take a Back Seat to China
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Transforming Drug Discovery and Disease Research—One Cell at a Time
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Scratching the Surface with a Novel Approach to Treating an Orphan Lung Disease
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A Dual Action Approach to Treating MASH
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Extending the Life of Transplanted Kidneys
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Overcoming Antimicrobial Resistance
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Using Targeted Radiotherapies to Treat Challenging CNS Cancers
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Hitting Previously Undruggable Targets with Oral Therapies
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Building Better Models of Human Diseases to Speed Drug Development
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Preventing Opioids from Countering the Benefits of Cancer Immunotherapies
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Better Living through Computational Chemistry
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Outsmarting a Clever One
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The Search for a New Approach to Male Contraception
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Crafting a One-and-Done Epigenetic Editor to Tackle Hepatitis B
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Fueling AI Drug Development with Patient Biology
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The Search for Better Obesity Treatments
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A Novel Approach to Treating Chronic Low Back Pain
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A Biologic Designed to Treat Acute Exacerbations of Asthma and COPD
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Turbocharging Drug Discovery with Health Data
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Revolutionizing the Production of Biologics with Algae
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Making Medicines for a World of People with Cancer
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Harnessing Myeloid Cells to Attack Cancer
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Drawing Lessons from the COVID Pandemic
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A Bet that Myostatins Can Muscle Out Obesity
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Making Whole-Eye Transplantation a Reality
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Synbio Companies Come to Grips with the One “Omic” that Matters
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Searching for Safer Pain Medications
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Bridging the Translational Divide in Healthcare AI
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Seeking Long-Term Pain Relief from a Drug-Free Injection
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Engaging Hard-to-Target Receptors with Antibodies that Activate
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An Insider’s View of the Patent Fights that Shaped the Biotech Industry
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Restoring Balance to the Immune System in Allergic Diseases
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Turning Natural Killers into Off-the-Shelf Therapies for Autoimmune Disease
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Combining an Antibody and siRNA to Treat Hepatitis B
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Looking at the Promise of GLP-1 Agonists Beyond Obesity
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An Off-the-Shelf Cancer Vaccine Faces a Final Clinical Hurdle in NSCLC
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A Nose for Attacking Brain Cancer
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An Unnatural Approach to Undruggable Targets
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Expanding the Drug Developer’s Chemical Universe
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Take 100 Megabytes a Day and Call Me in the Morning
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Extracting the Benefits of Psychedelics
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A Magellan that Circumnavigates Active Binding Sites
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A Very Meh-Ry Biotech Year and What’s Ahead in 2025
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Using Light to Biomanufacture a Steak
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Sit, Stay, and Heal: Bringing Precision Medicine to Dogs, then Humans
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Targeting the Undruggable Proteome
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Preventing a Deadly Disease by Detecting It Before It Becomes Cancer
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Getting Tumors to Say “Eat Me”
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Targeting the Dark Matter of the Genome to Treat Diseases
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Using AI to Discover Small Molecule Alternatives to Biologics
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A BET on a Novel Approach to Treat Autoimmune Conditions
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Cell Therapies that Can Do a Solid for People with Cancer
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Going to Extremes to Discover New Drugs
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Targeting Senescent Cells to Treat Aging-Related Diseases
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Bringing Cellular Diversity into Sharper Focus
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Developing Cancer Therapies for When Damage Control Goes Awry
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Delivering the Goods
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Swimming in the New Oil
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Does This Drug Represent “A Paradigm Shift for Small Molecule Drug Development?”
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Exploring the Promise and Peril of CRISPR
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Transforming Protein Engineering with Generative AI
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Delivering Peptide Therapies Orally
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Creating A Drug Delivery ARMMs Race
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A Seek and Destroy Approach to Disease-Causing Proteins
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Teaching Tolerance to Address Autoimmune Diseases
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A Bet That the Next Blockbuster May Already Be Inside You
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A Big Mac Attack to Fight Cancer
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Getting Animated about Bioliteracy
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Reshaping Clinical Trial Designs with Real-World Data
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Using Generative AI to Produce Precise Gene Editors
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Enabling the Nervous System to Repair Itself
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Overcoming Barriers to Delivering Large Molecules to the Brain
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Developing Complex Therapies to Tackle Complex Diseases
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How Solving a Problem with Genetic Medicines May Solve Another with Infectious Diseases
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Boosting the Power of Dendritic Cancer Vaccines
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Overcoming Resistance in Cancer with Chemistry
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Teaching an Old Drug a New Trick to Prevent Lyme Disease
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A New Class of Cell Therapies to Target Solid Tumors
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Targeting the Tumor Microenvironment with Lipid-Based Immunotherapies
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A Company Born from a Father Who Wore His Heart on His Sleeve
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Using AI to Improve Burn Care
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A Home for Biotech in the City that Never Sleeps
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Biopharma R&D Growing Stronger
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The Benefits of Having a Multitude of Cins
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